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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLL2 All Species: 12.42
Human Site: T2326 Identified Species: 45.56
UniProt: O14686 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14686 NP_003473.3 5262 564185 T2326 L G P S S G S T G E S Y G L S
Chimpanzee Pan troglodytes XP_519508 4802 529408 G2288 N S P M H S Q G Q Q F S G V S
Rhesus Macaque Macaca mulatta XP_001099471 5209 557834 T2273 L G P S S G S T G E S Y G L S
Dog Lupus familis XP_543684 5287 566794 T2318 L G S S S G S T G E G F G L S
Cat Felis silvestris
Mouse Mus musculus Q8BRH4 4903 540168 A2246 N Q D P F L Q A A Q N R V P G
Rat Rattus norvegicus XP_002729900 5543 595507 T2558 L G P N S G P T G E G Y G L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8IRW8 2431 259810
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 29.3 95.3 93.4 N.A. 27.8 85 N.A. N.A. N.A. N.A. N.A. N.A. 20 N.A. N.A. N.A.
Protein Similarity: 100 43.2 96 95.1 N.A. 41.7 87.7 N.A. N.A. N.A. N.A. N.A. N.A. 30.6 N.A. N.A. N.A.
P-Site Identity: 100 20 100 80 N.A. 0 80 N.A. N.A. N.A. N.A. N.A. N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 33.3 100 86.6 N.A. 13.3 86.6 N.A. N.A. N.A. N.A. N.A. N.A. 0 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 15 15 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 58 0 0 0 0 0 % E
% Phe: 0 0 0 0 15 0 0 0 0 0 15 15 0 0 0 % F
% Gly: 0 58 0 0 0 58 0 15 58 0 29 0 72 0 15 % G
% His: 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 58 0 0 0 0 15 0 0 0 0 0 0 0 58 0 % L
% Met: 0 0 0 15 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 29 0 0 15 0 0 0 0 0 0 15 0 0 0 0 % N
% Pro: 0 0 58 15 0 0 15 0 0 0 0 0 0 15 0 % P
% Gln: 0 15 0 0 0 0 29 0 15 29 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % R
% Ser: 0 15 15 43 58 15 43 0 0 0 29 15 0 0 72 % S
% Thr: 0 0 0 0 0 0 0 58 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 15 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _